Hoechst 33258

Name: Hoechst 33258

CAS Registry Number: 23491-45-4

CA Index Name: Phenol, 4-[5-(4-methyl-1-piperazinyl) [2,5'-bi-1H-benzimidazol]-2'-yl]-, hydrochloride (1:3)

Other Names: Phenol, 4-[5-(4-methyl-1-piperazinyl) [2,5'-bi-1H-benzimidazol]-2'-yl]-, trihydrochloride; Phenol, p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]- 2-benzimidazolyl]-, trihydrochloride; 2'-(4-Hydroxyphe-nyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimid-azole; 2-[2-(4-Hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazinyl)benzimidazole trihydrochloride; 2-[2-(4-Hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl)-benzimidazole trihydrochloride; 2-[2-(4-Hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-pi-perazyl)benzimidazole trichloride; 2-[2-(4-Hydroxyphe-nyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl)benzi-midazole-3HCl; 4-[5-[5-(4-Methyl-1-piperazinyl)-2-ben-zimidazolyl]-2-benzimidazolyl]phenol trihydrochloride; Bisbenzimide; Bisbenzimide (quenchant); Bisbenzimide trihydrochloride; H 33258; HOE 33258; Ho 33258; Hoechst 33258

Merck Index Number: Not listed

Chemical / Dye Class: Benzimidazole

Molecular Formula: C₂₅H₂₇Cl₃N₆O

Molecular Weight: 533.88

Physical Form: Dark yellow to tan powder with green cast

Solubility: Soluble in water, N,N-dimethyl formamide

Melting Point: > 300 °C

Absorption (λ_max): 352 nm, 343 nm

Emission (λ_max): 461 nm

Synthesis: Synthetic methods

Staining Applications: Nucleic acids; cells; bryos; microorganisms; nuclei; sperms

Biological Applications: Nucleic acid hybridization; detecting nucleic acids, cancer cells, spores, hepatitis C virus, human papilloma virus (HPV), single nucleotide polymorphism (SNP), stress biomarkers; nucleic acid amplification; nucleic acid quantification; nucleic acid sequencing; treating of cancer, allergy, autoimmune disease, neoplasia, sexually transmitted diseases

Industrial Applications: Not reported

Safety / Toxicity: Carcinogenicity; cytotoxicity; DNA damage; genotoxicity; neurotoxicity; oral toxicity; radiotoxicity; retinal toxicity

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