Hoechst 33342

Name: Hoechst 33342

CAS Registry Number: 23491-52-3

CA Index Name: 2,5'-Bi-1H-benzimidazole, 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-,hydrochloride (1:3)

Other Names: 2,5'-Bibenzimidazole, 2'-(p-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-; 2'-(4-Ethoxyphenyl)-5- (4-methyl- 1-piperazinyl)-2,5'-bi-1H-benzimidazole; 2-[2-(4-Ethoxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazinyl)benzimidazole; Bisbenzimide; HOE 33342; Ho 342; Hoechst 33342; NSC 334072

Merck Index Number: Not listed

Chemical / Dye Class: Benzimidazole

Molecular Formula: C₂₇H₃₁Cl₃N₆O

Molecular Weight: 561.93

Physical Form: Yellow to green powder

Solubility: Soluble in water, N,N-dimethyl formamide

Melting Point: > 300 °C

Boiling Point: 725.9 ± 70.0 °C, pressure: 760 Torr

pK_a: 11.08 ± 0.69, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic, temperature: 25 °C

Absorption (λ_max): 350 nm

Emission (λ_max): 461 nm

Synthesis: Synthetic methods

Staining Applications: Nucleic acids; cells; neurons; endothelial cells; inflammatory cells; cancer stem cells; animal mammary gland stem cells; hematopoietic stem cells; hepatocytes stem cells; human tumor cell; SV40 human corneal epithelial cell; microorganisms; nuclei; parasites; chromosomes; sperms

Biological Applications: Detecting abnormal gametes, apoptosis, human papilloma virus (HPV), single nucleotide polymorphism (SNP), mitochondrial membrane potential change, polynucleotides, proteins, peptides; nucleic acid amplification; nucleic acid quantification; nucleic acid sequencing; treating of cancer, Alzheimers disease, multiple sclerosis, epilepsy

Industrial Applications: Not reported

Safety / Toxicity: Carcinogenicity; cytotoxicity; DNA damage; genotoxicity; metabolic toxicity; mutagenicity; neurotoxicity; radiotoxicity; reproductive toxicity

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