DAPI

Name: DAPI

CAS Registry Number: 28718-90-3

CA Index Name: 1H-Indole-6-carboximidamide, 2-[4-(aminoiminomethyl)phenyl]-, dihydrochloride

Other Names: Indole-6-carboxamidine, 2-(p-amidino-phenyl)-, dihydrochloride; 4',6-Diamidino-2-phenylin-dole dihydrochloride; 6-Amidino-2-(4-amidinophenyl) indole dihydrochloride; DAPI

Merck Index Number: Not listed

Chemical / Dye Class: Indole

Molecular Formula: C₁₆H₁₇Cl₂N₅

Molecular Weight: 350.25

Physical Form: Yellow powder

Solubility: Soluble in water, N,N-dimethylformamide

Melting Point: > 200 °C

Absorption (λ_max): 358 nm, 342 nm

Emission (λ_max): 461 nm, 450 nm

Synthesis: Synthetic methods

Staining Applications: Nucleic acids; bacteria; cells; chromosomes; microorganisms; neuron-specific nuclear protein NeuN; polynucleotide; proteins

Biological Applications: Nuclear apoptosis assay; targeting drug to cerebral neuron; treating amyloidosis, neurodegenerative diseases, Alzheimer’s disease, Down’s syndrome, type II diabetes; monitoring bioaerosols

Industrial Applications: Not reported

Safety / Toxicity: No data available

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