BAPTA
Name: BAPTA
CAS Registry Number: 85233-19-8
CA Index Name: Glycine, N,N-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-
Other Names: 1,2-Bis(2-aminophenoxy)ethane-N,N',N', N-tetraacetic acid; 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N' -tetraacetic acid; Ethylenedioxybis(o-phenylenenitri-lo)tetraacetic acid; 2,2 -(Ethylenedioxy)dianiline-N,N,N,N'-tetraacetic acid; BAPTA
Merck Index Number: 957
Chemical / Dye Class: Aromatic
Molecular Formula: C22H24N2O10
Molecular Weight: 476.43
Physical Form: Beige powder
Solubility: Soluble in dimethyl sulfoxide
Melting Point: 149-159 °C
Boiling Point: 766.6 ± 60.0 °C, pressure: 760 Torr
pKa: 1.40 ± 0.10, most acidic, temperature: 25 °C; 5.96 ± 0.38, most basic, temperature 25 °C
Absorption (λmax): 209 nm, 254 nm, 203 nm, 274 nm
Emission (λmax): 363 nm
Synthesis: Synthetic methods
Staining Applications: Calcium ions; zinc ions; bone; proteins
Biological Applications: Calcium indicators; zinc indicators; treating acute cell death, cerebral infarction, myocardial infarction, hepatonecrosis, kidney ischemic necrosis, necrotizing pancreatitis, amyloidosis, atherosclerosis, diseases characterized by calcification and/or plaque formation, osteoporosis, Paget’s disease, heterotropic ossification, hypercalcemia, cancer, inflammation, diabetes mellitus, epilepsy, epithelial disorders, glaucoma, HIV-associated conditions, respiratory disorders, streptococcal infection, viral diseases
Industrial Applications: Inks
Safety / Toxicity: Carcinogenicity; cytotoxicity; excitotoxicity; hydrogen peroxide toxicity; neurotoxicity
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