Calcein AM

Name: Calcein AM

CAS Registry Number: 148504-34-1

CA Index Name: Glycine, N,N'-[[30,60-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester

Other Names: Calcein O, O'-diacetate tetrakis(acetoxy-methyl)ester; Glycine, N,N'-[[3',6'-bis(acetyloxy)-3-ox-ospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl] bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoe-thyl]-, bis[(acetyloxy)methyl] ester; Spiro[isoben-zofuran-1(3H),9'-[9H]xanthene], glycine derivative; Calcein AM; Calcein acetoxymethyl ester; NSC 689290

Merck Index Number: Not listed

Chemical / Dye Class: Xanthene

Molecular Formula: C₄₆H₄₆N₂O₂₃

Molecular Weight: 994.86

Physical Form: Colorless powder

Solubility: Soluble in dimethyl sulfoxide

Melting Point: > 250 °C

Boiling Point: 982.7 ± 65.0 °C, pressure: 760 Torr

pK_a: 2.66 ± 0.50, most basic, temperature: 25 °C

Absorption (λ_max): < 300 nm

Synthesis: Synthetic methods

Staining Applications: Calcium ions; zinc ions; bacteria; fungi; yeast; cells; cornea; erythrocytes; lymphocytes; microorganisms; neurons; Schwann cells; sperms; tissues

Biological Applications: Calcium indicators; zinc indicators; cytotoxicity assays; apoptosis assays; viability assays; labile iron pool assays; chemotaxis probes; cell adhesion probes; mitochondrial probes; P-glycoprotein probes; multi-drug resistance probes; treating atherosclerosis, cancer; ischemic disease

Industrial Applications: Not reported

Safety / Toxicity: Carcinogenicity; cytotoxicity; fish toxicity; nanoparticle toxicity; neurotoxicity; phototoxicity; ophthalmotoxicity; reproductive toxicity

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