Methylthiazoletetrazolium (MTT)
Name: Methylthiazoletetrazolium (MTT)
CAS Registry Number: 298-93-1
CA Index Name: 2H-Tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (1:1)
Other Names: 2H-Tetrazolium, 2-(4,5-dimethyl-2-thia-zolyl)-3,5-diphenyl, bromide; 3-(4,5-Dimethyl-2-thiazo-lyl)-2,5-diphenyl-2H-tetrazoliumbromide; 2,5-Diphenyl-3-(4,5-dimethylthiazol-2-yl)-2H-tetrazolium bromide; 2,5-Diphenyl-3-(4,5-dimethylthiazol-2-yl)tetrazolium bromide; 2-(4,5-Dimethylthiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide; 3-(4',5'-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide; 3-(4,5-Dimethyl-2-thiazo-lyl)-2,5-diphenyltetrazolium bromide; 3-(4,5-Di-methylthiazolyl)-2,5-diphenyl-2H-tetrazolium bromide; 3-(4,5-Dimethylthiazolyl)-2,5-diphenyltetrazolium bromide; MMT Tetrazolium; MTT; MTT Tetrazolium; Methylthiazoletetrazolium; NSC 60102; Methylthiazolyl-diphenyl Tetrazolium; Thiazolyl Blue Monotetrazolium; Thiazolyl blue; Thiazolyl blue (Sigma); Thiazolyl blue tetrazolium bromide
Merck Index Number: Not listed
Chemical / Dye Class: Tetrazolium salt
Molecular Formula: C18H16BrN5S
Molecular Weight: 414.32
Physical Form: Yellow to orange powder
Solubility: Soluble in water, ethanol, methanol, dimethyl sulfoxide
Melting Point: 195 °C (decompose)
Absorption (λmax): 378 nm, 242 nm
Synthesis: Synthetic methods
Staining Applications: Apoptotic and necrotic cells; cells; endospores; glutathione peroxidase; lyases; neurons; nucleic acids; oospores; serum cholinesterase; skin; sperms; tissues
Biological Applications: Cell viability assay; microbial growth assays; DNA quantification assays; tissue viability assays; detecting enzymes; measuring membrane potential; treating Alzheimer’s disease, asthma, cancer
Industrial Applications: Display devices; photographic materials
Safety / Toxicity: Aquatic toxicity; bacterial toxicity; carcinogenicity; cytotoxicity; dental toxicity; DNA damage; embryotoxicity; genotoxicity; immunotoxicity; mitochondrial toxicity; nephrotoxicity; neurotoxicity; phototoxicity; skin toxicity
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